The present invention describes novel nitrosated and/or nitrosylated
nonsteroidal antiinflammatory compounds, and novel compositions comprising
at least one nitrosated and/or nitrosylated nonsteroidal antiinflammatory
compound, and, optionally, at least one compound that donates, transfers
or releases nitric oxide, elevates endogenous levels of
endothelium-derived relaxing factor, stimulates endogenous synthesis of
nitric oxide or is a substrate for nitric oxide synthase. The present
invention also provides methods for treating, preventing and/or reducing
inflammation, pain, and fever; decreasing or reversing the
gastrointestinal, renal and other toxicities resulting from the use of
nonsteroidal antiinflammatory drugs; treating and/or preventing
gastrointestinal disorders; treating inflammatory disease states and
disorders; and treating and/or preventing ophthalmic diseases or
disorders.