Disclosed are novel compounds of the formula: and the pharmaceutically
acceptable salts and solvates thereof. D and E are different groups
wherein one is N and the other is CR.sup.50. Examples of groups
comprising Substituent A include heteroaryl, aryl, heterocycloalkyl,
cycloalkyl, aryl, alkynyl, alkenyl, aminoalkyl, alkyl or amino. Examples
of groups comprising Substituent B include aryl and heteroaryl. Also
disclosed is a method of treating a chemokine mediated diseases, such as,
cancer, angiogenisis, angiogenic ocular diseases, pulmonary diseases,
multiple sclerosis, rheumatoid arthritis, osteoarthritis, stroke and
cardiac reperfusion injury, pain (e.g., acute pain, acute and chronic
inflammatory pain, and neuropathic pain) using a compound of formula IA.