Isolated and purified platelet voltage dependent calcium channel (VDCC)
1 subunit polypeptides, and nucleic acid molecules encoding the
same. Recombinant host cells, recombinant nucleic acids and recombinant proteins
are also disclosed, along with methods of producing each. Isolated and purified
antibodies to platelet VDCC 1 subunit polypeptides, and methods
of producing the same, are also disclosed. Platelet VDCC 1 subunit
polypeptides have biological activity in calcium transport. Thus, therapeutic and
diagnostic methods involving this activity are also disclosed.