Novel C2,8-disubstituted adenosine derivatives disclosed herein have been
found to be potent adenosine receptor agonists, in particular for the A2A
receptor. The said compounds have biological activity against conditions
such as hypertension, ischemic heart disease, ischemic brain disease,
psychosis and wound healing. Further, the invention also discloses a
process for the preparation of such compounds and pharmaceutical
compositions comprising them.