The invention relates to methods and compositions for the selection and
development of novel pharmacological agents or novel medicaments having
properties or mechanisms of action which are original. The invention
specifically describes the characterization and identification of the
functional role of several constitutive elements of the central nervous
system playing a role in the metabolism or transport of xanthurenic acid
(XA) or involved in receiving and/or transducing the signal mediated by
this substance. Said targets are new tools for the definition and
selection of novel synthetic chemical substances, interfering with said
targets and modulating the functions of XA in order to benefit from the
pharmacological or medicamentous advantages thereof. The invention can be
primarily used to treat neurological or mental pathologies or diseases.