The present invention relates to a crystal of bicalutamide having a
defined form, as well as economical and industrially practical production
methods of bicalutamide and a crystal thereof, which are superior in
environmental benignity and safety.Accordingly, the present invention
provides a production method of bicalutamide represented by the formula
(I): ##STR00001## which includes at least a step of reacting a compound
represented by the formula (3): ##STR00002## with an oxidizing agent, a
production method of a crystal of bicalutamide, as well as a crystal form
of bicalutamide as defined by X-ray diffraction (XRD) or solid .sup.13C
NMR measurement.