In one aspect, the invention provides xylose isomerase enzymes,
polynucleotides encoding the enzymes, methods of making and using these
polynucleotides and polypeptides. The polypeptides of the invention can
be used in a variety of agricultural and industrial contexts. For
example, the polypeptides of the invention can be used for converting
glucose to fructose or for manufacturing high content fructose syrups in
large quantities. Other examples include use of the polypetides of the
invention in confectionary, brewing, alcohol and soft drinks production,
and in diabetic foods and sweetners.