The invention provides an isolated polypeptide containing the amino acid
sequence of SEQ ID NO: 14, 16, 18, 20, 22 or 24. The invention also
provides an isolated polypeptide containing a) an amino acid sequence
having at least 50% amino acid identity with SEQ ID NO: 10, and b) an
amino acid sequence selected from SEQ ID NOS: 14, 16, 18, 20, 22, or 24;
or a conservative variant thereof. The invention further provides an
isolated polypeptide containing the amino acid sequence of SEQ ID NO: 2,
4, 6, or 8. The invention also provides a method for identifying a
compound that modulates a COX-1 variant by contacting an isolated COX-1
variant or a COX-1 variant over-expressed in a genetically engineered
cell with a compound and determining the level of an indicator which
correlates with modulation of a COX-1 variant, where an alteration in the
level of the indicator as compared to a control level indicates that the
compound is a compound that modulates the COX-1 variant.