Human Ck.beta.-9 polypeptides and DNA (RNA) encoding such chemokine
polypeptides and a procedure for producing such polypeptides by
recombinant techniques is disclosed. Also disclosed are methods for
utilizing such Ck.beta.-9 polypeptides for the treatment of leukemia,
tumors, chronic infections, autoimmune disease, fibrotic disorders, wound
healing and psoriasis. Antagonists against such polypeptides and their
use as a therapeutic to treat rheumatoid arthritis, autoimmune and
chronic inflammatory and infective diseases, allergic reactions,
prostaglandin-independent fever and bone marrow failure are also
disclosed. Diagnostic assays are also disclosed which detect the presence
of mutations in the Ck.beta.-9 coding sequence and over-expression of the
Ck.beta.-9 protein.