Processing systems and methods comprise a separation device that, in use,
performs a separation process including separation of red blood cells
from blood or a suspension containing red blood cells. The systems and
methods include an outlet line coupled to the separation device to remove
red blood cells from the separation device, at least in part, while the
separation process occurs. A sensor associated with the outlet line
senses hematocrit of red blood cells removed from the separation device
and generates a sensed hematocrit output. A controller is coupled to the
separation device to control removal of red blood cells from the
separation device based, at least in part, upon the sensed hematocrit
output.