Compounds of formula (I) ##STR00001## are novel VR1 antagonists that are
useful in treating pain, inflammatory thermal hyperalgesia, urinary
incontinence and bladder overactivity, wherein X.sub.1, X.sub.2, X.sub.3,
X.sub.4, X.sub.5, R.sub.5, R.sub.6, R.sub.7, R.sub.8a, R.sub.8b, R.sub.9,
Z.sub.1, Z.sub.2, and L are defined in the description.