Compounds of the formula ##STR00001## where the variables are defined in
the specification have cytochrome P450RAI-1 and P450RAI-2 inhibitory
activity, and are suitable for treatment of mammals with conditions which
are treatable with retinoids, or which are controlled by or responsive to
the organism's native retinoic acid. Formulations containing the
compounds of the invention can also be co-administered with retinoids
and/or Vitamin A to enhance or prolong the effects of medications
containing retinoids, Vitamin A, or of the organism's native retinoic
acid.