The present invention relates to novel compounds and formulations thereof
which compounds are ligands, e.g., agonists or antagonists, for a
metabotropic glutamate receptor or a NAALADase enzyme or both. The
present invention also relates to methods of modulating the activity of a
metabotropic glutamate receptor or a NAALADase enzyme or both, e.g., in a
subject in need thereof, using a compound or formulation of the present
invention. The present invention also relates to methods of treating a
subject suffering from a chronic or acute disease, malady or condition
due at least in part to an abnormality in the activity of an endogenous
metabotropic glutamate receptor or a NAALADase enzyme or both, using a
compound or formulation of the present invention.