The present invention relates to compounds of Formula I, and
pharmaceutically acceptable salts or solvates thereof, or solvates of
such salts, ##STR00001## which compounds inhibit carboxypeptidase U and
thus can be used in the prevention and treatment of diseases associated
with carboxypeptidase U. In further aspects, the invention relates to
compounds of the invention for use in therapy; to processes for
preparation of such new compounds; to pharmaceutical compositions
containing at least one compound of the invention, or a pharmaceutically
acceptable salt or solvate thereof, as active ingredient; and to the use
of the active compounds in the manufacture of medicaments for the medical
use indicated above.