The present invention provides a method of reducing or inhibiting
osteoclast development induced by the receptor for activation of nuclear
factor kappa B ligand (RANKL), comprising the step of contacting said
osteoclast, or a precursor of the osteoclast, with a pharmacologically
effective dose of compounds such as diferuloylmethane, guggulsterone,
1'-Acetoxychavicol or analogues thereof.