Methods of inhibiting various enzymes and treating various conditions are
provided that include administering to a subject a compound of Structure
I or IB, a pharmaceutically acceptable salt thereof, a tautomer thereof,
or a pharmaceutically acceptable salt of the tautomer. Compounds having
the Structure I and IB have the following structures and have the
variables described herein. Such compounds may be used to prepare
medicaments for use in inhibiting various enzymes and for use in treating
conditions mediated by such enzymes. ##STR00001##