The inventors succeeded in isolating a novel hemopoietin receptor gene
(NR10) using a sequence predicted from the extracted motif conserved in
the amino acid sequences of known hemopoietin receptors. It was expected
that two forms of NR10 exists, a transmembrane type and soluble form.
Expression of the former type was detected in tissues containing
hematopoietic cells. Thus, NR10 is a novel hemopoietin receptor molecule
implicated in the regulation of the immune system and hematopoiesis in
vivo. These novel receptors are useful in screening for novel
hematopoietic factors capable of functionally binding to the receptor, or
developing medicines to treat diseases related with the immune system or
hematopoietic system.