Methods, reagents and kits for diagnosing and treating cancer such as
kidney or colorectal cancer are disclosed. An immunoassay for detecting
kidney or colorectal cancer is based on the relative change of the
ADAMTSL4 protein in urine or blood compared with normal tissue. An
immunohistochemical assay for detecting kidney or colorectal cancer is
based on the relative absence of labeled antibody binding to cancerous
tissue, compared with normal tissue.