Disclosed are medical devices comprising one or more surfaces, one or more
SAM molecules attached to the one or more surfaces of the medical device,
and one or more therapeutic agents attached to the one or more
self-assembled monolayer molecules. Also disclosed are medical devices
comprising one or more surfaces, one or more self-assembled monolayer
molecules attached to the one or more surfaces of the medical device, one
or more linkers comprising a first functional group and a second
functional group, the first functional group attached to the
self-assembled monolayer molecule and a therapeutic agent attached to the
second functional group. The therapeutic agent may be attached to the SAM
molecule via a linker. The present invention also concerns methods of
administering a therapeutic agent to a subject, comprising contacting the
subject with one of the medical devices set forth herein.