The invention provides compounds of formula I or a pharmaceutically
acceptable salt or ester thereof formula I
##STR00001##
wherein the symbols have the meaning as defined in the description. Said
compounds are inhibitors of cathepsin K and/or cathepsin S and are useful
for the treatment of diseases and medical conditions in which cathepsin K
and or cathepsin S is implicated, e.g. various disorders including
neuropathic pain, inflammation, rheumatoid arthritis, osteoarthritis,
osteoporosis, multiple sclerosis and tumours.