The present invention relates to novel muteins of human fibroblast growth
factor 21 with reduced capacity of O-glycosylation when expressed in
yeast compared to wild-type human FGF-21. Both protein and the respective
encoding nucleic acid species are disclosed. The invention also embodies
vectors and host cells for the propagation of said nucleic acid sequences
and the production of said muteins. Also disclosed are methods for
treating type 2 diabetes, obesity, or metabolic syndrome.