The present invention provides a means of economically, quickly and
efficiently designing a physiologically active peptide to a target
protein. Specifically, the present invention provides a method of
designing a physiologically active peptide characterized in that, to
design a physiologically active peptide capable of binding to a target
site comprising a consecutive or non-consecutive amino acid sequence in a
target protein, a computerized processing is carried out for extracting a
preferable amino acid sequence by calculating intermolecular energy etc.;
an apparatus therefor; a program for executing the above-described
processing by a computer; and a computer-readable recording medium
containing the program.