An automatic method for the registration of prone and supine computed
tomographic colonography data is provided. The method improves the
radiologist's overall interpretation efficiency as well as provides a
basis for combining supine/prone computer-aided detection results
automatically. The method includes determining (centralized) paths or
axes of the colon from which relatively stationary points of the colon
are matched for both supine and prone positions. Stretching and/or
shrinking of either the supine or prone path perform registration of
these points. The matching and registration occurs in an iterative and
recursive manner and is considered finished based on one or more decision
criteria.