A system and method of interaction between a computer, such as a desktop computer, and a mobile device include storing an identifier on the mobile device and the computer. A set of settings are stored in the computer referenced to the identifier for the mobile device. A connection method is selected from a plurality of connection methods. Upon connection of the mobile device to the computer pursuant to the selected method, the identifier stored in the mobile device is compared with the identifier stored on the computer. Interaction between the connected mobile device and the computer is controlled as a function of the stored set of settings if corresponding identifiers are found.