The Advanced Instrument Controller (AIC) is a stand-alone low-to-medium performance microcontroller with versatile interface and operating options. A tightly coupled MCM design incorporates a CPU, volatile and non-volatile memories, an analog ASIC, a resistor ASIC, internal oscillator, an agile analog capability to implement a gain, offset, impedance, and filter control on all input channels, and an embedded smart power convertor. The AIC uses switch matrices built from micro-mechanical systems technology to reconfigure the signal lines. It also has in-situ reprogrammability and state preservation capability for discontinuous operations. It is designed to operate under extreme conditions of temperature, shock, and radiation and is characterized by ultra-low power requirements, size, and weight.