Enantiomerically enriched disubstituted tetrahydrofurans, tetrahydrothiophenes, pyrrolidines and cyclopentanes are disclosed that reduce the chemotaxis and respiratory burst leading to the formation of damaging oxygen radicals of polymorphonuclear leukocytes during an inflammatory or immune response. The compounds exhibit this biological activity by acting as PAF receptor antagonists, by inhibiting the enzyme 5-lipoxygenase, or by exhibiting dual activity, i. e., by acting as both a PAF receptor antagonist and inhibitor of 5-lipoxygenase. It has been determined that 5-lipoxygenase activity, oral availability, and stability in vivo (for example, glucuronidation rate) can vary significantly among the optical isomers of the disclosed compounds.

Os tetrahydrofurans, os tetrahydrothiophenes, os pyrrolidines e os cyclopentanes disubstituted enriquecidos Enantiomerically são divulgados que reduzem os chemotaxis e o estouro respiratory que conduzem à formação de radicais prejudiciais do oxigênio de leukocytes polymorphonuclear durante uma resposta inflammatory ou imune. Os compostos exibem esta atividade biológica agindo como antagonistas do receptor de PAF, inibindo o enzyme 5-lipoxygenase, ou exibindo a atividade dupla, isto é, agindo como um antagonista do receptor de PAF e o inibidor de 5-lipoxygenase. Determinou-se que a atividade 5-lipoxygenase, a disponibilidade oral, e a estabilidade em vivo (para o exemplo, a taxa do glucuronidation) podem variar significativamente entre os isomers óticos dos compostos divulgados.