The invention provides materials and methods for modeling human blood vessels. Including panels of anatomically accurate vascular phantoms, such as carotid artery phantoms, comprising a range of stenotic conditions and other geometric variations; methods of making anatomically accurate vascular phantoms using stereolithography with an input data set representation of a natural vascular lumenal surface to construct an anatomically accurate vascular phantom comprising a physical representation of the surface; and methods of using the subject phantoms and panels of phantoms, such as methods of measuring a parameter of fluid flow through a panel of anatomically accurate vascular phantoms comprising a range of stenotic conditions.