Human REQUIEM polypeptides and DNA (RNA) encoding such REQUIEM and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such REQUIEM for the treatment of a susceptibility to viral infection, tumorogenesis and to diseases and defects in the control of embryogenesis and tissue homeostasis, and the nucleic acid sequences described above may be employed in an assay for ascertaining such susceptibility. Antagonists against such REQUIEM and their use as a therapeutic to treat Alzheimer's disease, Parkinson's disease, rheumatoid arthritis, septic shock, sepsis, stroke, CNS inflammation, osteoporosis, ischemia reperfusion injury, cell death associated with cardiovascular disease, polycystic kidney disease, apoptosis of endothelial cells in cardiovascular disease, degenerative liver disease, MS, ALS, cererbellar degeneration, ischemic injury, myocardial infarction, AIDS, myelodysplastic syndromes, aplastic anemia, male pattern baldness, and head injury damage are also disclosed. Also disclosed are diagnostic assays for detecting diseases related to mutations in the nucleic acid sequences and altered concentrations of the polypeptides. Also disclosed are diagnostic assays for detecting mutations in the polynucleotides encoding REQUIEM polypeptide and for detecting altered levels of the polypeptide in a host.

Os polypeptides humanos de REQUIEM e o DNA (RNA) que codificam tal REQUIEM e um procedimento para produzir tais polypeptides por técnicas recombinant são divulgados. São divulgados também os métodos para utilizar tal REQUIEM para o tratamento de um susceptibility à infecção viral, tumorogenesis e às doenças e aos defeitos no controle do embryogenesis e da homeostase do tecido, e as seqüências do ácido nucleic descritas acima podem ser empregadas em um assay para verificar tal susceptibility. Os antagonistas de encontro a tal REQUIEM e a seu uso como therapeutic tratar a doença de Alzheimer, a doença de Parkinson, o arthritis rheumatoid, choque séptico, o sepsis, o curso, o inflammation do CNS, o osteoporosis, o ferimento do reperfusion do ischemia, a morte da pilha associada com a doença cardiovascular, a doença polycystic do kidney, o apoptosis de pilhas endothelial na doença cardiovascular, a doença de fígado degenerative, o MS, o ALS, o degeneration cererbellar, ferimento isquêmico, o infarction myocardial, o AIDS, syndromes myelodysplastic, o anemia aplastic, o baldness masculino do teste padrão, e os danos de ferimento principal são divulgados também. São divulgados também os assays diagnósticos para detectar as doenças relacionadas aos mutations nas seqüências do ácido nucleic e nas concentrações alteradas dos polypeptides. São divulgados também os assays diagnósticos para detectar mutations nos polynucleotides que codificam o polypeptide de REQUIEM e para detectar níveis alterados do polypeptide em um anfitrião.