A delivery device having a first chamber containing an osmotic agent, a
membrane forming a wall of the first chamber through which fluid is
imbibed by osmosis, a second chamber containing a beneficial agent to be
delivered, and a moveable piston separating the two chambers. In fluid
communication with the second chamber is an orifice which comprises a slit
valve. In the presence of pressure, the beneficial agent pushes through
the slit, opening up a channel for delivery of the beneficial agent and
creating flow. Because the slit remains closed in the absence of flow (or
when the pressure is below the pressure required to open the slit), back
diffusion of external fluids is eliminated when the slit is closed, which
prevents contamination of the beneficial agent in the second chamber by
external fluids. In addition, forward diffusion of the beneficial agent
out of the capsule is prevented when the slit is closed. The slit valve
opens only to the minimum dimension required to allow the flow generated
by the osmotic pumping rate. The slit valve also allows a flow path to
open around any obstruction in the slit valve to prevent clogging.