The invention relates to subtype-selective NMDA receptor ligands and the use thereof for treating or preventing neuronal loss associated with stroke, ischemia, CNS trauma, hypoglycemia and surgery, as well as treating neuro-degenerative diseases including Alzheimer's disease, amyotrophic lateral sclerosis, Huntington's disease and Down's syndrome, treating or preventing the adverse consequences of the overstimulation of the excitatory amino acids, treating anxiety, psychosis, convulsions, aminoglycoside antibiotics-induced hearing loss, migraine headache, chronic pain, Parkinson's disease, glaucoma, CMV retinitis, urinary incontinence, opioid tolerance or withdrawal, and inducing anesthesia, as well as for enhancing cognition.

A invenção relaciona-se aos ligands subtype-selective do receptor de NMDA e ao uso disso para tratar ou impedir a perda neuronal associada com o curso, o ischemia, o trauma do CNS, o hypoglycemia e a cirurgia, as.well.as doenças neuro-neuro-degenerative de tratamento including a doença de Alzheimer, o sclerosis de lateral amyotrophic, a doença de Huntington e para baixo o syndrome, tratando ou impedindo as conseqüências adversas do overstimulation dos aminos-ácido excitatory, tratando a ansiedade, o psychosis, os convulsions, a perda de hearing antibiótico-induzida aminoglycoside, o headache do migraine, a dor crônica, a doença de Parkinson, o glaucoma, CMV retinitis, incontinence urinary, tolerância do opioid ou retirada, e induzindo o anesthesia, as.well.as para realçar a cognição.