Disclosed herein are quinoline derivatives having dual mechanistic properties, referred to in this patent document as "acetylcholine enhancers", i.e., compounds which evidence acetylcholinesterase (AChE) inhibition activity, and 5-HT3 receptor antagonist activity. A particularly preferred compound is 2-[2-(1-benzylpiperizin-4-yl) ethyl]-2,3-dihydro-9-methoxy-1H-pyrrolo [3,4-b] quinolin-1-one hemifumarate, referred to herein as Compound A ("Cm.A").

Se divulgan adjunto los derivados del quinoline que tienen características mecánicas duales, designadas en este documento de la patente "reforzadores del acetylcholine", es decir, los compuestos que evidencian actividad de la inhibición del acetylcholinesterase (dolor), y actividad del antagonista del receptor 5-HT3. Un compuesto particularmente preferido es 2-[2-(1-benzylpiperizin-4-yl) hemifumarate de ethyl]-2,3-dihydro-9-methoxy-1H-pyrrolo [ 3,4-b ] quinolin-1-one, designado adjunto el compuesto A ("Cm.A").