Cross-linked particles are provided that are useful for delivery of pharmaceutical agents. The particles comprise at least one polymeric compound and a spacer compound, where the polymeric compound and the spacer each comprise reactive carboxyl, hydrazidyl, amino and/or thiol groups. The particles are cross-linked via covalent linkage of the reactive groups on the polymer and spacer respectively. Compositions comprising pharmaceutical agents contained within the particles are disclosed. Methods for preparing the particles, for encapsulating pharmaceutical agents within the particles, and for using the particles for controlled release of the pharmaceutical agent within the patient also are provided.

Cross-linked as partículas são contanto que útil para a entrega de agentes pharmaceutical. As partículas compreendem ao menos um composto polymeric e um composto do espaçador, onde o composto polymeric e o espaçador cada um compreendam carboxyl reactive, os amino e/ou de thiol grupos do hydrazidyl. As partículas cross-linked através do enlace covalent dos grupos reactive no polímero e no espaçador respectivamente. As composições que compreendem os agentes pharmaceutical contidos dentro das partículas são divulgadas. Os métodos para preparar as partículas, para encapsulating agentes pharmaceutical dentro das partículas, e para usar as partículas para liberação controlada do agente pharmaceutical dentro do paciente são fornecidos também.