Selective inhibitors of the cPLA.sub.2 enzymes are provided which are of use in controlling a wide variety of inflammatory diseases. The inhibitors of the present invention have the general formula ##STR1##

Os inibidores seletivos dos enzymes PLA.SUB.2 são fornecidos que são do uso em controlar uma variedade larga de doenças inflammatory. Os inibidores da invenção atual têm o ## geral do ## STR1 da fórmula

 
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