Compounds having the formula:
##STR1##
wherein
R.sub.1 -R.sub.5 are independently selected from hydrogen, alkyl of 1 to 6
carbon atoms, alkenyl of 2 to 6 carbon atoms, alkynyl of 2 to 6 carbon
atoms, perhaloalkyl of 1 to 6 carbon atoms, cycloalkyl of 3 to 10 carbon
atoms, heterocycloalkyl of 3 to 10 carbon members, aryl, heteroaryl,
halogen, --CN, --NO.sub.2, --CO.sub.2 R.sub.6, --COR.sub.6, --OR.sub.6,
--SR.sub.6, --SOR.sub.6, --SO.sub.2 R.sub.6, --CONR.sub.7 R.sub.8,
--NR.sub.6 N(R.sub.7 R.sub.8), --N(R.sub.7 R.sub.8) or
W--Y--(CH.sub.2).sub.n --Z provided that at least one of R.sub.1 -R.sub.5
is not hydrogen; or R.sub.2 and R.sub.3 or R.sub.3 and R.sub.4, taken
together form a 3 to 7 membered heterocycloalkyl or 3 to 7 membered
heteroaryl;
R.sub.6 and R.sub.7 are independently hydrogen, alkyl of 1 to 6 carbon
atoms, perhaloalkyl of 1 to 6 carbon atoms, or aryl;
R.sub.8 is hydrogen, alkyl of 1 to 6 carbon atoms, perhaloalkyl of 1 to 6
carbon atoms, cycloalkyl of 3 to 10 carbon atoms, heterocycloalkyl of 3 to
10 members, aryl or heteroaryl, or
R.sub.7 and R.sub.8, taken together may form a 3 to 7 membered
heterocycloalkyl;
W is O, NR.sub.6, or is absent;
Y is --(CO)-- or --(CO.sub.2)--, or is absent;
Z is alkyl of 1 to 4 carbon atoms, --CN, --CO.sub.2 R.sub.6, COR.sub.6,
--CONR.sub.7 R.sub.8, --OCOR.sub.6, --NR.sub.6 COR.sub.7, --OCONR.sub.6,
--OR.sub.6, --SR.sub.6, --SOR.sub.6, --SO.sub.2 R.sub.6, SR6N(R7R8),
--N(R.sub.7 R.sub.8) or phenyl;
G is aryl or fused bicyclic heteroaryl;
X is a bond, --NH, alkyl of 1 to 6 carbon atoms, alkenyl of 1 to 6 carbon
atoms, alkoxy of 1 to 6 carbon atoms, thioalkyl of 1 to 6 carbon atoms,
alkylamino of 1 to 6 carbon atoms, or (CH)J;
J is alkyl of 1 to 6 carbon atoms, cycloalkyl of 3 to 7 carbon atoms,
phenyl or benzyl; and
n is an integer from 1 to 6; or a pharmaceutically acceptable salt
thereof, useful in the treatment of diseases associated with herpes
viruses including human cytomegalovirus, herpes simplex viruses,
Epstein-Barr virus, varicella-zoster virus, human herpesviruses-6 and -7,
and Kaposi herpesvirus.
Samenstellingen die de formule hebben: ## STR1 ## waarin R.sub.1 - R.sub.5 worden onafhankelijk geselecteerd uit waterstof, alkyl van 1 tot 6 koolstofatomen, alkenyl van 2 tot 6 koolstofatomen, alkynyl van 2 tot 6 koolstofatomen, perhaloalkyl van 1 tot 6 koolstofatomen, cycloalkyl van 3 tot 10 koolstofatomen, heterocycloalkyl van 3 tot 10 koolstofleden, aryl, heteroaryl, halogeen, -CN, -- NO.sub.2, -- CO.sub.2 R.sub.6, -- COR.sub.6, -- OR.sub.6, -- SR.sub.6, -- SOR.sub.6, -- SO.sub.2 R.sub.6, -- CONR.sub.7 R.sub.8, -- NR.sub.6 N(R.sub.7 R.sub.8), -- N(R.sub.7 R.sub.8) of W -- Y -- (CH.sub.2).sub.n z bepaalde dat minstens één van R.sub.1 - R.sub.5 is geen waterstof; of samen genomen R.sub.2 en R.sub.3 of R.sub.3 en R.sub.4, vormen membered heterocycloalkyl 3 tot 7 of membered heteroaryl 3 tot 7; R.sub.6 en R.sub.7 zijn onafhankelijk waterstof, alkyl van 1 tot 6 koolstofatomen, perhaloalkyl van 1 tot 6 koolstofatomen, of aryl; R.sub.8 is waterstof, alkyl van 1 tot 6 koolstofatomen, perhaloalkyl van 1 tot 6 koolstofatomen, cycloalkyl van 3 tot 10 koolstofatomen, heterocycloalkyl van 3 tot 10 leden, aryl of heteroaryl, of R.sub.7 en samen genomen R.sub.8, kan membered heterocycloalkyl vormen 3 tot 7; W is O, NR.sub.6, of is afwezig; Y is -- (CO) -- of -- (CO.sub.2) - -, of is afwezig; Z is alkyl van 1 tot 4 koolstofatomen, -CN, -- CO.sub.2 R.sub.6, COR.sub.6, -- CONR.sub.7 R.sub.8, -- OCOR.sub.6, -- NR.sub.6 COR.sub.7, -- OCONR.sub.6, -- OR.sub.6, -- SR.sub.6, -- SOR.sub.6, -- SO.sub.2 R.sub.6, SR6N (R7R8), -- N(R.sub.7 R.sub.8) of fenyl; G is aryl of gesmolten bicyclische heteroaryl; X is een band, -NH, alkyl van 1 tot 6 koolstofatomen, alkenyl van 1 tot 6 koolstofatomen, alkoxy van 1 tot 6 koolstofatomen, thioalkyl van 1 tot 6 koolstofatomen, alkylamino van 1 tot 6 koolstofatomen, of (CH)J; J is alkyl van 1 tot 6 koolstofatomen, cycloalkyl van 3 tot 7 koolstofatomen, phenyl of benzyl; en n is een geheel van 1 tot 6; of een farmaceutisch aanvaardbaar zout daarvan, nuttig in de behandeling van ziekten verbonden aan herpesvirussen met inbegrip van menselijke cytomegalovirus, herpes simplexvirussen, virus epstein-Barr, varicella-zoster virus, mens herpesviruses-6 en -7, en herpesvirus Kaposi.
