Corticotropin releasing factor (CRF) antagonists of formula I: ##STR1## and their use in treating anxiety, depression, and other psychiatric, neurological disorders as well as treatment of immunological, cardiovascular or heart-related diseases and colonic hypersensitivity associated with psychopathological disturbance and stress.

Corticotropin die factoren (CRF) bevrijdt antagonisten van formule I: ## STR1 ## en hun gebruik in het behandelen van bezorgdheid, depressie, en andere psychiatrische, neurologische wanorde evenals behandeling van immunologische, cardiovasculaire of op hart betrekking hebbende ziekten en de hypergevoeligheid van de dikke darm verbonden aan psychopathological storing en spanning.