Hydroxamic acids having the formula ##STR1## are useful in treating disease conditions mediated by TNF-.alpha., such as rheumatoid arthritis, osteoarthritis, sepsis, AIDS, ulcerative colitis, multiple sclerosis, Crohn's disease and degenerative cartilage loss.

Гидроксамовые кислоты имея ## ## STR1 формулы полезны в обрабатывая условиях заболеванием посредничанных TNF-.alpha., such as ревматоидный артрит, остеоартрит, sepsis, AIDS, ulcerative colitis, множественный склероз, заболевание Crohn's и вырожденческая потеря хрящевины.
 
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> Recombinant proteins with the immunoreactivity of hepatitis B virus e antigen (HBeAg), a process for the preparation thereof and the use thereof in immunoassays and vaccines

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