Tissue-destructive conditions related to excess protemase activity in a biological system are treated or prevented by administering to the system a composition which combines a tetracycline and a bisphosphonate in synergistic proteinase inhibiting amounts.

las condiciones Tejido-destructivas relacionadas con exceso de actividad del protemase en un sistema biológico son tratadas o prevenidas administrando al sistema una composición que combine un tetracycline y un bisphosphonate en cantidades que inhiben del proteinase sinérgico.