Peptide analogs of the high molecular weight kininogen domain 5 are potent inhibitors of angiogenesis. The peptides have the formula X.sub.1 -(HGLGHGHEQQHGKGH)-X.sub.2 (I) wherein X.sub.1 is from zero to 25 amino acids; X.sub.2 is from zero to 60 amino acids. Methods of inhibiting endothelial cell proliferation and angiogenesis are provided.

Os analogs do peptide do domínio elevado 5 do kininogen do peso molecular são inibidores potent do angiogenesis. Os peptides têm a fórmula X.sub.1 -(HGLGHGHEQQHGKGH)-X.sub.2 (I) wherein X.sub.1 é zero a 25 aminos-ácido; X.sub.2 é zero a 60 aminos-ácido. Os métodos de inibir o proliferation e o angiogenesis endothelial da pilha são fornecidos.