A murine model for human breast, ovarian and prostate cancer is provided. The model comprises either an immunodeficient mouse containing human primary breast, ovarian or prostate carcinoma tissue implanted within the gonadal fat pad, or an immunodeficient mouse containing human prostate or ovarian carcinoma tissue subcutaneously implanted therein. Methods of using the murine model, for example, to grow tumors and to screen treatments for breast, ovarian and/or prostate cancer are also provided.