An isolated and purified human protein activator of apoptosis is described.
A cDNA sequence which encodes the native kinase of death is disclosed as
well as the structural coding region and the amino acid residue sequence.
Methods are provided which employ the sequences to identify compounds that
modulate the biological and/or pharmacological activity of the activator
and hence regulate apoptosis. Biologically-effective antisense molecules,
as well as dominant negative mutant versions of the apoptosis activator
are described which are suitable for therapeutic use. The invention is
also drawn toward the study, prevention, diagnosis, and treatment of
pathophysiological disorders related to apoptosis.