##STR1##
Compounds of formula (I), and their pharmaceutically acceptable
derivatives, wherein R.sup.1 and R.sup.2 are optional substituents and
independently represent C.sub.1-6 alkyl, C.sub.2-6 alkenyl, optionally
substituted by CO.sub.2 H or CO.sub.2 (C.sub.1-6 alkyl), C.sub.2-6
alkynyl, halogen, C.sub.1-3 perfluoroalkyl, (CH.sub.2).sub.m Ar.sup.1,
(CH.sub.2).sub.m Het.sup.1, (CH.sub.2).sub.m CONR.sup.7 R.sup.8,
(CH.sub.2).sub.m CO.sub.2 R.sup.8, O(CH.sub.2).sub.q CO.sub.2 R.sup.8,
(CH.sub.2).sub.m COR.sup.8, (CH.sub.2).sub.m OR.sup.8, O(CH.sub.2).sub.p
OR.sup.8, (CH.sub.2).sub.m NR.sup.7 R.sup.8, CO.sub.2 (CH.sub.2).sub.q
NR.sup.7 R.sup.8, (CH.sub.2).sub.m CN, S(O).sub.n R.sup.8, SO.sub.2
NR.sup.7 R.sup.8, CONH(CH.sub.2).sub.m Ar.sup.1 or CONH(CH.sub.2).sub.m
Het.sup.1 ; R.sup.3 represents H, C.sub.1-6 alkyl, (CH.sub.2).sub.p
NR.sup.9 R.sup.10, SO.sub.2 R.sup.10, SO.sub.2 NR.sup.9 R.sup.10,
(CH.sub.2).sub.m CO.sub.2 R.sup.10, C.sub.2-6 alkenyl, C.sub.2-6 alkynyl,
(CH.sub.2).sub.m CONR.sup.9 R.sup.10, (CH.sub.2).sub.m CO.sub.2 R.sup.10,
(CH.sub.2).sub.p CN, (CH.sub.2).sub.p R.sup.10 or (CH.sub.2).sub.p
OR.sup.10 ; R.sup.4 represents H or C.sub.1-6 alkyl; R.sup.5 represents H
or OH; R.sup.6 represents phenyl optionally fused to a herterocyclic ring,
the group as a whole being optionally substituted; R.sup.7-10 are fully
defined herein and may independently represent Ar.sup.2 or Het.sup.2 ; Z
represents CO.sub.2 H, CONH(tetrazol-5-yl), CONHSO.sub.2 O(C.sub.1-4
alkyl), CO.sub.2 Ar.sup.3, CO.sub.2 (C.sub.1-6 alkyl), tetrazol-5-yl,
CONHSO.sub.2 Ar.sup.3, CONHSO.sub.2 (CH.sub.2).sub.q Ar.sup.3 or
CONHSO.sub.2 (C.sub.1-4 alkyl); Ar.sup.1-3 indenpendently represent
phenyl, naphthyl, or an aromatic heterocycle, which groups are optionally
fused and optionally substituted; and Het.sup.1 and Het.sup.2
independently represent a non-aromatic heterocycle which is optionally
substituted; are useful in the treatment of restenosis, renal failure and
pulmonary hypertension.
## del ## STR1 I residui della formula (i) ed i loro derivati farmaceuticamente accettabili, in cui R.sup.1 e R.sup.2 sono sostituenti facoltativi ed indipendentemente rappresentano C.sub.1-6 l'alchile, alchenile C.sub.2-6, facoltativamente sostituito da CO.sub.2 H o da CO.sub.2 (C.sub.1-6 alchile), C.sub.2-6 alkynyl, alogeno, perfluoroalkyl C.sub.1-3, (CH.sub.2).sub.m Ar.sup.1, (CH.sub.2).sub.m Het.sup.1, (CH.sub.2).sub.m CONR.sup.7 R.sup.8, (CH.sub.2).sub.m CO.sub.2 R.sup.8, O(CH.sub.2).sub.q CO.sub.2 R.sup.8, (CH.sub.2).sub.m COR.sup.8, (CH.sub.2).sub.m OR.sup.8, O(CH.sub.2).sub.p OR.sup.8, (CH.sub.2).sub.m NR.sup.7 R.sup.8, CO.sub.2 (CH.sub.2).sub.q NR.sup.7 R.sup.8, (CH.sub.2).sub.m CN, S(O).sub.n R.sup.8, SO.sub.2 NR.sup.7 R.sup.8, CONH(CH.sub.2).sub.m Ar.sup.1 o CONH(CH.sub.2).sub.m Het.sup.1; R.sup.3 rappresenta la H, alchile C.sub.1-6, (CH.sub.2).sub.p NR.sup.9 R.sup.10, SO.sub.2 R.sup.10, SO.sub.2 NR.sup.9 R.sup.10, (CH.sub.2).sub.m CO.sub.2 R.sup.10, C.sub.2-6 alchenile, alkynyl C.sub.2-6, (CH.sub.2).sub.m CONR.sup.9 R.sup.10, (CH.sub.2).sub.m CO.sub.2 R.sup.10, (CH.sub.2).sub.p CN, (CH.sub.2).sub.p R.sup.10 o (CH.sub.2).sub.p OR.sup.10; R.sup.4 rappresenta l'alchile H o C.sub.1-6; R.sup.5 rappresenta la H o l'OH; R.sup.6 rappresenta il fenile facoltativamente fuso ad un anello herterocyclic, il gruppo nell'insieme facoltativamente che si รจ sostituito; R.sup.7-10 completamente sono definiti qui e possono rappresentare indipendentemente Ar.sup.2 o Het.sup.2; La Z rappresenta l'alchile di CO.sub.2 H, di CONH(tetrazol-5-yl), di CONHSO.sub.2 O(C.sub.1-4), CO.sub.2 Ar.sup.3, CO.sub.2 (C.sub.1-6 alchile), tetrazol-5-yl, CONHSO.sub.2 Ar.sup.3, CONHSO.sub.2 (CH.sub.2).sub.q Ar.sup.3 o CONHSO.sub.2 (alchile C.sub.1-4); Ar.sup.1-3 indenpendently rappresenta il fenile, il naftile, o un heterocycle aromatico, che i gruppi facoltativamente sono fusi e facoltativamente si sostituiscono; e Het.sup.1 e Het.sup.2 rappresentano indipendentemente un heterocycle non aromatico che facoltativamente si sostituisce; sia utile nel trattamento del restenosis, dell'indebolimento renale e dell'ipertensione polmonare.
