The present invention provides prophylactic and therapeutic methods of treating the ductal epithelium of an exocrine gland, in particular a mammary gland, for disease, in particular cancer. The methods comprise contacting the ductal epithelium of the exocrine gland with an epithelium-destroying agent, preferably by ductal cannulation, so as to realize a prophylactic or therapeutic effect.

A invenção atual fornece métodos prophylactic e therapeutic de tratar o epithelium ductal de uma glândula exocrine, no detalhe uma glândula mammary, para a doença, no cancer particular. Os métodos compreendem contatar o epithelium ductal da glândula exocrine com um agente epithelium-destruindo, preferivelmente pelo cannulation ductal, para realizar um efeito prophylactic ou therapeutic.