Methods of treatment for osteoporosis in a human or other animal subject, comprising: administering a bone-active phosphonate to said subject, at a level of at least about 0.1 LED per day of said treatment; and administering an estrogen hormone to said subject at a level of from about 0.2 to about 0.8 LED per day of said treatment. The bone-active phosphonate is preferably a bisphosphonate, or a phosphonoalkyl phosphonate.

Métodos de tratamiento para el osteoporosis en el ser humano o el otro tema animal, abarcando: administrando un phosphonate hueso-activo al tema dicho, en un nivel por lo menos de cerca de 0.1 LED por día del tratamiento dicho; y administrando una hormona del estrógeno al tema dicho en un nivel de de cerca de 0.2 a cerca de 0.8 LED por día del tratamiento dicho. El phosphonate hueso-activo es preferiblemente un bisphosphonate, o un phosphonate del phosphonoalkyl.