A compound of the formula ##STR1## wherein R.sup.1, R.sup.2 R.sup.3, R.sup.4 R.sup.5, R.sup.6, R.sup.7, R.sup.8, R.sup.9 and Ar are as defined above, useful in the treatment of a condition selected from the group consisting of arthritis, cancer, and other diseases characterized by matrix metalloproteinase or mammalian reprolysin activity. In addition, the compounds of the present invention may be used in combination therapy with standard non-steroidal anti-inflammatory drugs (NSAID'S), COX-2 inhibitors and analgesics, and in combination with cytotoxic drugs such as adriamycin, daunomycin, cis-platinum, etoposide, taxol, taxotere and other alkaloids, such as vincristine, in the treatment of cancer.

Um composto do ## do ## STR1 da fórmula wherein R.sup.1, R.sup.2 R.sup.3, R.sup.4 R.sup.5, R.sup.6, R.sup.7, R.sup.8, R.sup.9 e Ar são como definidos acima, uns úteis no tratamento de uma circunstância selecionada do arthritis consistindo do grupo, do cancer, e das outras doenças caracterizaram pelo metalloproteinase da matriz ou pela atividade mammalian do reprolysin. Além, os compostos da invenção atual podem ser usados na terapia da combinação com as drogas anti-inflammatory non-non-steroidal padrão (NSAID'S), os inibidores COX-2 e os analgesics, e em combinação com drogas cytotoxic tais como o adriamycin, o daunomycin, a cis-platina, o etoposide, o taxol, o taxotere e os outros alcalóides, tais como o vincristine, no tratamento do cancer.