The present invention provides a new simple polymeric matrix tablet that
delivers highly soluble drugs over long periods of time and is easy to
manufacture. More specifically, the drug is first granulated with or
encapsulated in a swellable polymer, such as a gum, to form a granule.
This granule is disposed in a matrix of a more swellable, erodible
polymer, such as HPMC or Polyethyleneoxide, and optionally includes
pectin. The more swellable erodible polymer has a diffusion rate
coefficient which is greater than the diffusion rate coefficient of the
relatively less swellable polymer. It is this difference in diffusion rate
coefficients between the first and second polymers which controls the rate
of drug release and allows the system to approach zero order drug delivery
over the drug release period. Other advantages which the present invention
holds over existing systems including ease of manufacturing and
reproducibility of release profiles under well defined hydrodynamic
conditions. The delivery system of the present invention has a potential
to maximally release its drug content in a controlled manner over a long
time period while achieving complete dissolution.