The invention provides hybrid oligonucleotides having phosphorothioate or phosphorodithioate internucleotide linkages, and both deoxyribonucleosides and ribonucleosides or 2'-substituted ribonucleosides. Such hybrid oligonucleotides have superior properties of duplex formation with RNA, nuclease resistance, and RNase H activation.

De uitvinding verstrekt hybride oligonucleotides die phosphorothioate of phosphorodithioate internucleotideaaneenschakelingen hebben, en zowel deoxyribonucleosides als ribonucleosides of 2'-gesubstitueerde ribonucleosides. Dergelijke hybride oligonucleotides hebben superieure eigenschappen van duplexvorming met RNA, nucleaseweerstand, en de activering van RNase H.