Novel polypeptides, designated Apaf-1, which are capable of modulating apoptosis are provided. Compositions including Apaf-1 chimeras, nucleic acid encoding Apaf-1, and antibodies to Apaf-1 are also provided.

Os polypeptides da novela, designados Apaf-1, que são capazes de modular o apoptosis são fornecidos. As composições including os chimeras Apaf-1, o ácido nucleic que codificam Apaf-1, e os antibodies a Apaf-1 são fornecidas também.