Bacterial, yeast and animal cells and methods for overexpressing recombinant heparanase in cellular systems, methods of purifying recombinant heparanase therefrom and modified heparanase species which serve as precursors for generating highly active heparanase by proteolysis.

Bacteriano, fermento e pilhas e métodos do animal para overexpressing o heparanase recombinant nos sistemas celulares, métodos de purifying o heparanase recombinant therefrom e as espécies modificadas do heparanase que servem como precursors para gerar o heparanase altamente ativo pelo proteolysis.