Tricyclic heteroaromatic compounds and derivatives are described as well as
methods for the preparation and pharmaceutical compositions of same, which
are useful as inhibitors of matrix metalloproteinases, particularly
gelatinase A, collagenase-3, and stromelysin-1 and for the treatment of
multiple sclerosis, atherosclerotic plaque rupture, aortic aneurysm, heart
failure, left ventricular dilation, restenosis, periodontal disease,
corneal ulceration, treatment of burns, decubital ulcers, wound healing,
cancer, inflammation, pain, arthritis, osteoporosis, renal disease, or
other autoimmune or inflammatory disorders dependent upon tissue invasion
by leukocytes or other activated migrating cells, acute and chronic
neurodegenerative disorders including stroke, head trauma, spinal cord
injury, Alzheimer's disease, amyotrophic lateral sclerosis, cerebral
amyloid angiopathy, AIDS, Parkinson's disease, Huntington's disease, prion
diseases, myasthenia gravis, and Duchenne's muscular dystrophy.
Os compostos e os derivatives heteroaromatic tricyclic são descritos assim como métodos para a preparação e as composições pharmaceutical de mesmos, que são úteis como inibidores de metalloproteinases da matriz, particularmente gelatinase A, collagenase-3, e stromelysin-1 e para o tratamento do sclerosis múltiplo, a ruptura atherosclerotic da chapa, aneurysm aortic, falha de coração, dilation ventricular esquerdo, restenosis, doença peridental, ulceration corneal, tratamento das queimaduras, ulcers decubital, fere healing, cancer, inflammation, dor, arthritis, osteoporosis, doença renal, ou outros disorders autoimmune ou inflammatory dependentes da invasão do tecido por leukocytes ou por outros disorders neurodegenerative ativados das pilhas migrar, os agudos e os crônicos including o curso, trauma principal, spinal cord ferimento, a doença de Alzheimer, o sclerosis de lateral amyotrophic, angiopathy amyloid cerebral, o AIDS, a doença de Parkinson, a doença de Huntington, as doenças do prion, os gravis do myasthenia, e o dystrophy muscular de Duchenne.
