HNEAA81 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are screening methods for identifying agonists and antagonists of the interaction of the HNEAA81 receptor and its ligands in the design of protocols for the treatment of infections such as bacterial, fungal, protozoan and viral infections, particularly infections caused by HIV-1 or HIV-2; pain; cancers; anorexia; bulimia; asthma; Parkinson's disease; acute heart failure; hypotension; hypertension; urinary retention; osteoporosis; angina pectoris; myocardial infarction; ulcers; asthma; allergies; benign prostatic hypertrophy; and psychotic and neurological disorders, including anxiety, schizophrenia, manic depression, delirium, dementia, severe mental retardation and dyskinesias, such as Huntington's disease or Gilles dela Tourett's syndrome, among others and diagnostic assays for such conditions.

Os polypeptides HNEAA81 e os polynucleotides e os métodos para produzir tais polypeptides por técnicas recombinant são divulgados. São divulgados também os métodos de seleção para identificar os agonists e os antagonistas da interação do receptor HNEAA81 e seus ligands no projeto dos protocolos para o tratamento das infecções tais como bacteriano, fungal, protozoário e infecções viral, particularmente infecções causadas por HIV-1 ou HIV-2; dor; cancers; anorexia; bulimia; asthma; Doença de Parkinson; falha de coração aguda; hypotension; hypertension; retenção urinary; osteoporosis; angina pectoris; infarction myocardial; ulcers; asthma; allergies; hypertrophy prostatic benigno; e disorders psychotic e neurological, including a ansiedade, a esquizofrenia, o depression manic, o delirium, o dementia, o retardation mental severo e as discinesias, tais como o syndrome de Tourett da doença de Huntington ou do dela de Gilles, entre outro e assays diagnósticos para tais circunstâncias.